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KMID : 0353320110350010041
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Oral Biology Research
2011 Volume.35 No. 1 p.41 ~ p.46
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The effect of medicinal plants extracts on the cell growth in the MG-63 human osteoblast cell
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Lee Sook-Young
Jang Eun-Sook
Jin Seung-Chan
Piao Zheng-Gang
Park Sang-Hyeok
Kim Su-Gwan
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Abstract
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In the present study we investigated the proliferative effect of human osteoblast MG-63 cell treated with 8 spp. medicinal plant extracts to screen the active compounds. Plant extracts were prepared by ethanol extraction method from Carthamus tinctorius seeds, Rhynchosia volubilis seeds, Camellia japonica leaves, Acanthopanax senticosus root and wood, Eucommia ulmoides bark, Chaenomeles sinensis flesh, Sambucus sieboldiana stem, Achyranthes japonica whole plant. A osteoblast proliferation test was conducted by MTT assay on 24 wellplate. Among 8 extracts, R. volubilis seeds and C. japonica leaves showed relatively strong stimulatory activity on osteoblast proliferation at the concentration of 12.5-200 /mL. Also Chaenomeles sinensis flesh, Sambucus sieboldiana stem, Achyranthes japonica whole plant showed cell viability of above 80% at the concentration of 25 /mL. These results suggested that 3 extracts may have beneficial effects on alveolar bone health through the proliferation of osteoblast cells.
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KEYWORD
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Camellia japonica, Carthamus tinctorius, Osteoblast, Proliferation, Rhynchosia volubilis
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